On quantification errors of   R 2 *  $$ {R}_2^{\ast } $$  and proton density fat fraction mapping in trabecularized bone marrow in the static dephasing regime.

Kronthaler, Sophia; Diefenbach, Maximilian N; Boehm, Christof; Zamskiy, Mark; Makowski, Marcus R; Baum, Thomas; Sollmann, Nico; Karampinos, Dimitrios C

doi:10.1002/mrm.29279

journal article

Document type:: Journal Article
Author(s):: Kronthaler, Sophia; Diefenbach, Maximilian N; Boehm, Christof; Zamskiy, Mark; Makowski, Marcus R; Baum, Thomas; Sollmann, Nico; Karampinos, Dimitrios C
Title:: On quantification errors of R 2 * $$ {R}_2^{\ast } $$ and proton density fat fraction mapping in trabecularized bone marrow in the static dephasing regime.
Abstract:: PURPOSE: To study the effect of field inhomogeneity distributions in trabecularized bone regions on the gradient echo (GRE) signal with short TEs and to characterize quantification errors on R 2 * $$ {R}_2^{\ast } $$ and proton density fat fraction (PDFF) maps when using a water-fat model with an exponential R 2 * $$ {R}_2^{\ast } $$ decay model at short TEs. METHODS: Field distortions were simulated based on a trabecular bone micro CT dataset. Simulations were performed for different bone volume fractions (BV/TV) and for different bone-fat composition values. A multi-TE UTE acquisition was developed to acquire multiple UTEs with random order to minimize eddy currents. The acquisition was validated in phantoms and applied in vivo in a volunteer's ankle and knee. Chemical shift encoded MRI (CSE-MRI) based on a Cartesian multi-TE GRE scan was acquired in the spine of patients with metastatic bone disease. RESULTS: Simulations showed that signal deviations from the exponential signal decay at short TEs were more prominent for a higher BV/TV. UTE multi-TE measurements reproduced in vivo the simulation-based predicted behavior. In regions with high BV/TV, the presence of field inhomogeneities induced an R 2 * $$ {R}_2^{\ast } $$ underestimation in trabecularized bone marrow when using CSE-MRI at 3T with a short TE. CONCLUSION: R 2 * $$ {R}_2^{\ast } $$ can be underestimated when using short TEs (<2 ms at 3 T) and a water-fat model with an exponential R 2 * $$ {R}_2^{\ast } $$ decay model in multi-echo GRE acquisitions of trabecularized bone marrow.
Journal title abbreviation:: Magn Reson Med
Year:: 2022
Journal volume:: 88
Journal issue:: 3
Pages contribution:: 1126-1139
Fulltext / DOI:: doi:10.1002/mrm.29279
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/35481686
Print-ISSN:: 0740-3194
TUM Institution:: Institut für Diagnostische und Interventionelle Radiologie (Prof. Makowski); Professur für Neuroradiologie (Prof. Zimmer)
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