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Title:

Hippocampus mediates nocebo impairment of opioid analgesia through changes in functional connectivity.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Bingel, Ulrike; Wiech, Katja; Ritter, Christoph; Wanigasekera, Vishvarani; Ní Mhuircheartaigh, Roisin; Lee, Michael C; Ploner, Markus; Tracey, Irene
Abstract:
The neural mechanisms underlying placebo analgesia have attracted considerable attention over the recent years. In contrast, little is known about the neural underpinnings of a nocebo-induced increase in pain. We previously showed that nocebo-induced hyperalgesia is accompanied by increased activity in the hippocampus that scaled with the perceived level of anxiety. As a key node of the neural circuitry of perceived threat and fear, the hippocampus has recently been proposed to coordinate defens...     »
Journal title abbreviation:
Eur J Neurosci
Year:
2022
Journal volume:
56
Journal issue:
2
Pages contribution:
3967-3978
Fulltext / DOI:
doi:10.1111/ejn.15687
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35537867
Print-ISSN:
0953-816X
TUM Institution:
1411; Klinik und Poliklinik für Neurologie (Prof. Hemmer); Professur für Human Pain Research (Prof. Ploner)
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