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Title:

Cognate microglia-T cell interactions shape the functional regulatory T cell pool in experimental autoimmune encephalomyelitis pathology.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Haimon, Zhana; Frumer, Gal Ronit; Kim, Jung-Seok; Trzebanski, Sébastien; Haffner-Krausz, Rebecca; Ben-Dor, Shifra; Porat, Ziv; Muschaweckh, Andreas; Chappell-Maor, Louise; Boura-Halfon, Sigalit; Korn, Thomas; Jung, Steffen
Abstract:
Microglia, the parenchymal brain macrophages of the central nervous system, have emerged as critical players in brain development and homeostasis. The immune functions of these cells, however, remain less well defined. We investigated contributions of microglia in a relapsing-remitting multiple sclerosis paradigm, experimental autoimmune encephalitis in C57BL/6 x SJL F1 mice. Fate mapping-assisted translatome profiling during the relapsing-remitting disease course revealed the potential of micro...     »
Journal title abbreviation:
Nat Immunol
Year:
2022
Journal volume:
23
Journal issue:
12
Pages contribution:
1749-1762
Fulltext / DOI:
doi:10.1038/s41590-022-01360-6
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36456736
Print-ISSN:
1529-2908
TUM Institution:
Molekulare Immunologie (Prof. Knolle)
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