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Titel:

MicroRNA-21-Dependent Macrophage-to-Fibroblast Signaling Determines the Cardiac Response to Pressure Overload.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Ramanujam, Deepak; Schön, Anna Patricia; Beck, Christina; Vaccarello, Paula; Felician, Giulia; Dueck, Anne; Esfandyari, Dena; Meister, Gunter; Meitinger, Thomas; Schulz, Christian; Engelhardt, Stefan
Abstract:
BACKGROUND: Cardiac macrophages (cMPs) are increasingly recognized as important regulators of myocardial homeostasis and disease, yet the role of noncoding RNA in these cells is largely unknown. Small RNA sequencing of the entire miRNomes of the major cardiac cell fractions revealed microRNA-21 (miR-21) as the single highest expressed microRNA in cMPs, both in health and disease (25% and 43% of all microRNA reads, respectively). MiR-21 has been previously reported as a key microRNA driving tissu...     »
Zeitschriftentitel:
Circulation
Jahr:
2021
Band / Volume:
143
Heft / Issue:
15
Seitenangaben Beitrag:
1513-1525
Volltext / DOI:
doi:10.1161/CIRCULATIONAHA.120.050682
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33550817
Print-ISSN:
0009-7322
TUM Einrichtung:
Institut für Humangenetik; Institut für Pharmakologie und Toxikologie
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