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Titel:

Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect.

Dokumenttyp:
Article; Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Tadros, Rafik; Francis, Catherine; Xu, Xiao; Vermeer, Alexa M C; Harper, Andrew R; Huurman, Roy; Kelu Bisabu, Ken; Walsh, Roddy; Hoorntje, Edgar T; Te Rijdt, Wouter P; Buchan, Rachel J; van Velzen, Hannah G; van Slegtenhorst, Marjon A; Vermeulen, Jentien M; Offerhaus, Joost Allard; Bai, Wenjia; de Marvao, Antonio; Lahrouchi, Najim; Beekman, Leander; Karper, Jacco C; Veldink, Jan H; Kayvanpour, Elham; Pantazis, Antonis; Baksi, A John; Whiffin, Nicola; Mazzarotto, Francesco; Sloane, Geraldine; Suz...     »
Abstract:
The heart muscle diseases hypertrophic (HCM) and dilated (DCM) cardiomyopathies are leading causes of sudden death and heart failure in young, otherwise healthy, individuals. We conducted genome-wide association studies and multi-trait analyses in HCM (1,733 cases), DCM (5,521 cases) and nine left ventricular (LV) traits (19,260 UK Biobank participants with structurally normal hearts). We identified 16 loci associated with HCM, 13 with DCM and 23 with LV traits. We show strong genetic correlatio...     »
Zeitschriftentitel:
Nat Genet
Jahr:
2021
Band / Volume:
53
Heft / Issue:
2
Seitenangaben Beitrag:
128-134
Volltext / DOI:
doi:10.1038/s41588-020-00762-2
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33495596
Print-ISSN:
1061-4036
TUM Einrichtung:
Institut für Humangenetik
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