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Title:

Fetal Bradycardia Caused by Monogenic Disorders-A Review of the Literature.

Document type:
Journal Article; Review
Author(s):
Westphal, Dominik S; Hauser, Michael; Beckmann, Britt-Maria; Wolf, Cordula M; Hessling, Gabriele; Oberhoffer-Fritz, Renate; Wacker-Gussmann, Annette
Abstract:
Introduction: The standard obstetric definition of fetal bradycardia is a sustained fetal heart rate < 110 bpm over at least 10 min. Fetal bradycardia can be the first and only prenatal presentation of a heart disease. We present an overview on different genetic disorders that should be taken into consideration in case of diagnosed fetal bradycardia. Methods: A literature review was conducted using a PubMed- and OMIM-based search for monogenetic disorders causing fetal bradycardia in September 2022. Results: The review on the literature identified nine monogenic diseases that could lead to fetal bradycardia. Four of these disorders can be associated with extracardiac findings. Discussion: Genetic testing should be considered in cases with fetal bradycardia, especially in cases of additional extracardiac findings. Broad sequencing techniques and improved prenatal phenotyping could help to establish a diagnosis in an increasing number of cases.
Journal title abbreviation:
J Clin Med
Year:
2022
Journal volume:
11
Journal issue:
23
Fulltext / DOI:
doi:10.3390/jcm11236880
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36498454
TUM Institution:
Institut für Humangenetik (Prof. Winkelmann); Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (DHM) (Prof. Schunkert); Klinik für Kinderkardiologie und angeborene Herzfehler (DHM) (Prof. Ewert); Klinik und Poliklinik für Innere Medizin I, Kardiologie (Prof. Laugwitz)
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