Benutzer: Gast  Login
Titel:

Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Singanayagam, Aran; Footitt, Joseph; Marczynski, Matthias; Radicioni, Giorgia; Cross, Michael T.; Finney, Lydia J.; Trujillo-Torralbo, Maria-Belen; Calderazzo, Maria Adelaide; Zhu, Jie; Aniscenko, Julia; Clarke, Thomas B.; Molyneaux, Philip L.; Bartlett, Nathan W.; Moffatt, Miriam F.; Cookson, William O.; Wedzicha, Jadwiga A.; Evans, Christopher M.; Boucher, Richard C.; Kesimer, Mehmet; Lieleg, Oliver; Mallia, Patrick; Johnston, Sebastian L.
Abstract:
The respiratory tract surface is protected from inhaled pathogens by a secreted layer of mucus rich in mucin glycoproteins. Abnormal mucus accumulation is a cardinal feature of chronic respiratory diseases but the relationship between mucus and pathogens during exacerbations is poorly understood. We identified elevations in airway MUC5AC and MUC5B concentrations during spontaneous and experimentally-induced chronic obstructive pulmonary disease (COPD) exacerbations. MUC5AC was more sensitive to...     »
Dewey Dezimalklassifikation:
500 Naturwissenschaften
Zeitschriftentitel:
Journal of Clinical Investigation
Jahr:
2022
Jahr / Monat:
2022-03
Nachgewiesen in:
Scopus
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.1172/jci120901
WWW:
https://www.jci.org/articles/view/120901
Verlag / Institution:
American Society for Clinical Investigation
E-ISSN:
1558-8238
Publikationsdatum:
03.03.2022
Semester:
WS 21-22
TUM Einrichtung:
Fachgebiet für Biomechanik
 BibTeX