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Title:

A Multi-Scale and Multi-Technique Approach for the Characterization of the Effects of Spatially Fractionated X-ray Radiation Therapies in a Preclinical Model.

Document type:
Journal Article
Author(s):
Romano, Mariele; Bravin, Alberto; Mittone, Alberto; Eckhardt, Alicia; Barbone, Giacomo E; Sancey, Lucie; Dinkel, Julien; Bartzsch, Stefan; Ricke, Jens; Alunni-Fabbroni, Marianna; Hirner-Eppeneder, Heidrun; Karpov, Dmitry; Giannini, Cinzia; Bunk, Oliver; Bouchet, Audrey; Ruf, Viktoria; Giese, Armin; Coan, Paola
Abstract:
The purpose of this study is to use a multi-technique approach to detect the effects of spatially fractionated X-ray Microbeam (MRT) and Minibeam Radiation Therapy (MB) and to compare them to seamless Broad Beam (BB) irradiation. Healthy- and Glioblastoma (GBM)-bearing male Fischer rats were irradiated in-vivo on the right brain hemisphere with MRT, MB and BB delivering three different doses for each irradiation geometry. Brains were analyzed post mortem by multi-scale X-ray Phase Contrast Imagi...     »
Journal title abbreviation:
Cancers (Basel)
Year:
2021
Journal volume:
13
Journal issue:
19
Fulltext / DOI:
doi:10.3390/cancers13194953
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34638437
TUM Institution:
595; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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