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Document type:
Journal Article
Author(s):
von Heydebrand, Franziska; Fuchs, Maximilian; Kunz, Meik; Voelkl, Simon; Kremer, Anita N; Oostendorp, Robert A J; Wilke, Jochen; Leitges, Michael; Egle, Alexander; Mackensen, Andreas; Lutzny-Geier, Gloria
Title:
Protein kinase C-β-dependent changes in the glucose metabolism of bone marrow stromal cells of chronic lymphocytic leukemia.
Abstract:
Survival of chronic lymphocytic leukemia (CLL) cells critically depends on the support of an adapted and therefore appropriate tumor microenvironment. Increasing evidence suggests that B-cell receptor-associated kinases such as protein kinase C-β (PKCβ) or Lyn kinase are essential for the formation of a microenvironment supporting leukemic growth. Here, we describe the impact of PKCβ on the glucose metabolism in bone marrow stromal cells (BMSC) upon CLL contact. BMSC get activated by CLL contact...     »
Journal title abbreviation:
Stem Cells
Year:
2021
Journal volume:
39
Journal issue:
6
Pages contribution:
819-830
Fulltext / DOI:
doi:10.1002/stem.3352
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33539629
Print-ISSN:
1066-5099
TUM Institution:
Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie
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