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Title:

PD-1 Blockade Elicits Ongoing Remission in Two Cases of Refractory Microsatellite-Stable Cancer Harboring a POLE Mutation.

Document type:
Case Reports
Author(s):
Schenck, Kristina; Masetti, Michael; Pfarr, Nicole; Lorenzen, Sylvie
Abstract:
INTRODUCTION: In the last decade, immune-checkpoint therapy has led to a break-through in the treatment of cancer across all entities, while molecular markers have grown in importance for the choice of the appropriate chemotherapeutic agents. Accordingly, in 2017, the US Food and Drug Administration approved the programmed cell death protein 1 inhibitor pembrolizumab, a tissue agnostic cancer drug, for the treatment of cancer that displays microsatellite instability, regardless of histological e...     »
Journal title abbreviation:
Oncology Research and Treatment
Year:
2022
Journal volume:
45
Journal issue:
4
Pages contribution:
222-226
Fulltext / DOI:
doi:10.1159/000521332
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34875656
Print-ISSN:
2296-5270
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie
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