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Titel:

Sensitive and robust liquid biopsy-based detection of PIK3CA mutations in hormone-receptor-positive metastatic breast cancer patients.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Suppan, Christoph; Graf, Ricarda; Jahn, Stephan; Zhou, Qing; Klocker, Eva Valentina; Bartsch, Rupert; Terbuch, Angelika; Kashofer, Karl; Regitnig, Peter; Lindenmann, Joerg; Posch, Florian; Gerritsmann, Hanno; Jost, Philipp J; Heitzer, Ellen; Dandachi, Nadia; Balic, Marija
Abstract:
BACKGROUND: The benefit of alpelisib in hormone-receptor-positive (HR+) metastatic breast cancer patients provided clinical evidence for the increasing importance of PIK3CA testing. We performed a comparison of liquid biopsy and tissue-based detection of PIK3CA mutations. MATERIALS AND METHODS: PIK3CA hotspot mutation analysis using a high-resolution SiMSen-Seq assay was performed in plasma from 93/99 eligible patients with HR+/HER2- breast cancer. Additionally, mFAST-SeqS was used to estimate t...     »
Zeitschriftentitel:
Br J Cancer
Jahr:
2022
Band / Volume:
126
Heft / Issue:
3
Seitenangaben Beitrag:
456-463
Volltext / DOI:
doi:10.1038/s41416-021-01601-9
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34754095
Print-ISSN:
0007-0920
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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