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Titel:

Extra-hematopoietic immunomodulatory role of the guanine-exchange factor DOCK2.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Scharler, Cornelia; Poupardin, Rodolphe; Ebner-Peking, Patricia; Wolf, Martin; Schreck, Christina; Brachtl, Gabriele; Cronemberger Andrade, Andre; Krisch, Linda; Daheron, Laurence; Schallmoser, Katharina; Jürchott, Karsten; Küchler, Judit; Stachelscheid, Harald; Volk, Hans-Dieter; Oostendorp, Robert A J; Strunk, Dirk
Abstract:
Stromal cells interact with immune cells during initiation and resolution of immune responses, though the precise underlying mechanisms remain to be resolved. Lessons learned from stromal cell-based therapies indicate that environmental signals instruct their immunomodulatory action contributing to immune response control. Here, to the best of our knowledge, we show a novel function for the guanine-exchange factor DOCK2 in regulating immunosuppressive function in three human stromal cell models...     »
Zeitschriftentitel:
Commun Biol
Jahr:
2022
Band / Volume:
5
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s42003-022-04078-1
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36380073
TUM Einrichtung:
Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie
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