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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Jafari, Mehrnoosh; Schumacher, Adrian-Minh; Snaidero, Nicolas; Ullrich Gavilanes, Emily M; Neziraj, Tradite; Kocsis-Jutka, Virág; Engels, Daniel; Jürgens, Tanja; Wagner, Ingrid; Weidinger, Juan Daniel Flórez; Schmidt, Stephanie S; Beltrán, Eduardo; Hagan, Nellwyn; Woodworth, Lisa; Ofengeim, Dimitry; Gans, Joseph; Wolf, Fred; Kreutzfeldt, Mario; Portugues, Ruben; Merkler, Doron; Misgeld, Thomas; Kerschensteiner, Martin 
Title:
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation. 
Abstract:
Cortical pathology contributes to chronic cognitive impairment of patients suffering from the neuroinflammatory disease multiple sclerosis (MS). How such gray matter inflammation affects neuronal structure and function is not well understood. In the present study, we use functional and structural in vivo imaging in a mouse model of cortical MS to demonstrate that bouts of cortical inflammation disrupt cortical circuit activity coincident with a widespread, but transient, loss of dendritic spines...    »
 
Journal title abbreviation:
Nat Neurosci 
Year:
2021 
Journal volume:
24 
Journal issue:
Pages contribution:
355-367 
Print-ISSN:
1097-6256 
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)