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Document type:
Article; Journal Article
Author(s):
Eira, Jessica; Magalhães, Joana; Macedo, Nídia; Pero, Maria Elena; Misgeld, Thomas; Sousa, Mónica M; Bartolini, Francesca; Liz, Márcia A
Title:
Transthyretin Promotes Axon Growth via Regulation of Microtubule Dynamics and Tubulin Acetylation.
Abstract:
Transthyretin (TTR), a plasma and cerebrospinal fluid protein, increases axon growth and organelle transport in sensory neurons. While neurons extend their axons, the microtubule (MT) cytoskeleton is crucial for the segregation of functional compartments and axonal outgrowth. Herein, we investigated whether TTR promotes axon elongation by modulating MT dynamics. We found that TTR KO mice have an intrinsic increase in dynamic MTs and reduced levels of acetylated α-tubulin in peripheral axons. In...    »
Journal title abbreviation:
Front Cell Dev Biol
Year:
2021
Journal volume:
9
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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