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Title:

The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system.

Document type:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Tüshaus, Johanna; Müller, Stephan A; Shrouder, Joshua; Arends, Martina; Simons, Mikael; Plesnila, Nikolaus; Blobel, Carl P; Lichtenthaler, Stefan F
Abstract:
Proteolytic ectodomain shedding of membrane proteins is a fundamental mechanism to control the communication between cells and their environment. A key protease for membrane protein shedding is ADAM17, which requires a non-proteolytic subunit, either inactive Rhomboid 1 (iRhom1) or iRhom2 for its activity. While iRhom1 and iRhom2 are co-expressed in most tissues and appear to have largely redundant functions, the brain is an organ with predominant expression of iRhom1. Yet, little is known about...     »
Journal title abbreviation:
FASEB J
Year:
2021
Journal volume:
35
Journal issue:
11
Fulltext / DOI:
doi:10.1096/fj.202100936R
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34613632
Print-ISSN:
0892-6638
TUM Institution:
657; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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