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Title:

Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Bosch-Queralt, Mar; Cantuti-Castelvetri, Ludovico; Damkou, Alkmini; Schifferer, Martina; Schlepckow, Kai; Alexopoulos, Ioannis; Lütjohann, Dieter; Klose, Christian; Vaculčiaková, Lenka; Masuda, Takahiro; Prinz, Marco; Monroe, Kathryn M; Di Paolo, Gilbert; Lewcock, Joseph W; Haass, Christian; Simons, Mikael
Abstract:
Proregenerative responses are required for the restoration of nervous-system functionality in demyelinating diseases such as multiple sclerosis (MS). Yet, the limiting factors responsible for poor CNS repair are only partially understood. Here, we test the impact of a Western diet (WD) on phagocyte function in a mouse model of demyelinating injury that requires microglial innate immune function for a regenerative response to occur. We find that WD feeding triggers an ageing-related, dysfunctiona...     »
Journal title abbreviation:
Nat Metab
Year:
2021
Journal volume:
3
Journal issue:
2
Pages contribution:
211-227
Fulltext / DOI:
doi:10.1038/s42255-021-00341-7
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33619376
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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