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Title:

TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Gouna, Garyfallia; Klose, Christian; Bosch-Queralt, Mar; Liu, Lu; Gokce, Ozgun; Schifferer, Martina; Cantuti-Castelvetri, Ludovico; Simons, Mikael
Abstract:
Upon demyelinating injury, microglia orchestrate a regenerative response that promotes myelin repair, thereby restoring rapid signal propagation and protecting axons from further damage. Whereas the essential phagocytic function of microglia for remyelination is well known, the underlying metabolic pathways required for myelin debris clearance are poorly understood. Here, we show that cholesterol esterification in male mouse microglia/macrophages is a necessary adaptive response to myelin debris...     »
Journal title abbreviation:
J Exp Med
Year:
2021
Journal volume:
218
Journal issue:
10
Fulltext / DOI:
doi:10.1084/jem.20210227
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34424266
Print-ISSN:
0022-1007
TUM Institution:
657; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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