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Titel:

Mitochondrial Phenotypes in Parkinson's Diseases-A Focus on Human iPSC-Derived Dopaminergic Neurons.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Review
Autor(en):
Heger, Leonie M; Wise, Rachel M; Hees, J Tabitha; Harbauer, Angelika B; Burbulla, Lena F
Abstract:
Established disease models have helped unravel the mechanistic underpinnings of pathological phenotypes in Parkinson's disease (PD), the second most common neurodegenerative disorder. However, these discoveries have been limited to relatively simple cellular systems and animal models, which typically manifest with incomplete or imperfect recapitulation of disease phenotypes. The advent of induced pluripotent stem cells (iPSCs) has provided a powerful scientific tool for investigating the underly...     »
Zeitschriftentitel:
Cells
Jahr:
2021
Band / Volume:
10
Heft / Issue:
12
Volltext / DOI:
doi:10.3390/cells10123436
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34943944
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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