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Titel:

White matter aging drives microglial diversity.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Safaiyan, Shima; Besson-Girard, Simon; Kaya, Tuğberk; Cantuti-Castelvetri, Ludovico; Liu, Lu; Ji, Hao; Schifferer, Martina; Gouna, Garyfallia; Usifo, Fumere; Kannaiyan, Nirmal; Fitzner, Dirk; Xiang, Xianyuan; Rossner, Moritz J; Brendel, Matthias; Gokce, Ozgun; Simons, Mikael
Abstract:
Aging results in gray and white matter degeneration, but the specific microglial responses are unknown. Using single-cell RNA sequencing from white and gray matter separately, we identified white matter-associated microglia (WAMs), which share parts of the disease-associated microglia (DAM) gene signature and are characterized by activation of genes implicated in phagocytic activity and lipid metabolism. WAMs depend on triggering receptor expressed on myeloid cells 2 (TREM2) signaling and are ag...     »
Zeitschriftentitel:
Neuron
Jahr:
2021
Band / Volume:
109
Heft / Issue:
7
Seitenangaben Beitrag:
1100-1117.e10
Volltext / DOI:
doi:10.1016/j.neuron.2021.01.027
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33606969
Print-ISSN:
0896-6273
TUM Einrichtung:
657; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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