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Title:

Differential Effects of Fingolimod and Natalizumab on B Cell Repertoires in Multiple Sclerosis Patients.

Document type:
Article; Journal Article
Author(s):
Kowarik, M C; Astling, D; Lepennetier, G; Ritchie, A; Hemmer, B; Owens, G P; Bennett, Jeffrey L
Abstract:
Natalizumab and fingolimod are effective multiple sclerosis (MS) therapies that disrupt lymphocyte migration but have differential effects on B cell maturation and trafficking. We investigated their effects on peripheral blood (PB) and cerebrospinal fluid (CSF) B cell repertoires using next-generation deep sequencing. Paired CSF and PB B cell subsets (naïve, CD27+ memory, and CD27-IgD- double-negative B cells and plasmablasts) were collected by applying flow cytometry at baseline and after 6 mon...     »
Journal title abbreviation:
Neurotherapeutics
Year:
2021
Journal volume:
18
Journal issue:
1
Pages contribution:
364-377
Fulltext / DOI:
doi:10.1007/s13311-020-00975-7
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33258072
Print-ISSN:
1933-7213
TUM Institution:
Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik
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