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Title:

Diverse epigenetic mechanisms maintain parental imprints within the embryonic and extraembryonic lineages.

Document type:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Andergassen, Daniel; Smith, Zachary D; Kretzmer, Helene; Rinn, John L; Meissner, Alexander
Abstract:
Genomic imprinting and X chromosome inactivation (XCI) require epigenetic mechanisms to encode allele-specific expression, but how these specific tasks are accomplished at single loci or across chromosomal scales remains incompletely understood. Here, we systematically disrupt essential epigenetic pathways within polymorphic embryos in order to examine canonical and non-canonical genomic imprinting as well as XCI. We find that DNA methylation and Polycomb group repressors are indispensable for a...     »
Journal title abbreviation:
Dev Cell
Year:
2021
Journal volume:
56
Journal issue:
21
Pages contribution:
2995-3005.e4
Fulltext / DOI:
doi:10.1016/j.devcel.2021.10.010
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34752748
Print-ISSN:
1534-5807
TUM Institution:
Institut für Pharmakologie und Toxikologie
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