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Titel:

Completion of neuronal remodeling prompts myelination along developing motor axon branches.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Wang, Mengzhe; Kleele, Tatjana; Xiao, Yan; Plucinska, Gabriela; Avramopoulos, Petros; Engelhardt, Stefan; Schwab, Markus H; Kneussel, Matthias; Czopka, Tim; Sherman, Diane L; Brophy, Peter J; Misgeld, Thomas; Brill, Monika S
Abstract:
Neuronal remodeling and myelination are two fundamental processes during neurodevelopment. How they influence each other remains largely unknown, even though their coordinated execution is critical for circuit function and often disrupted in neuropsychiatric disorders. It is unclear whether myelination stabilizes axon branches during remodeling or whether ongoing remodeling delays myelination. By modulating synaptic transmission, cytoskeletal dynamics, and axonal transport in mouse motor axons,...     »
Zeitschriftentitel:
J Cell Biol
Jahr:
2021
Band / Volume:
220
Heft / Issue:
4
Volltext / DOI:
doi:10.1083/jcb.201911114
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33538762
Print-ISSN:
0021-9525
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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