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Titel:

NFAT5/TonEBP Limits Pulmonary Vascular Resistance in the Hypoxic Lung by Controlling Mitochondrial Reactive Oxygen Species Generation in Arterial Smooth Muscle Cells.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Laban, Hebatullah; Siegmund, Sophia; Zappe, Maren; Trogisch, Felix A; Heineke, Jörg; Torre, Carolina De La; Fisslthaler, Beate; Arnold, Caroline; Lauryn, Jonathan; Büttner, Michael; Mogler, Carolin; Kato, Katsuhiro; Adams, Ralf H; Kuk, Hanna; Fischer, Andreas; Hecker, Markus; Kuebler, Wolfgang M; Korff, Thomas
Abstract:
Chronic hypoxia increases the resistance of pulmonary arteries by stimulating their contraction and augmenting their coverage by smooth muscle cells (SMCs). While these responses require adjustment of the vascular SMC transcriptome, regulatory elements are not well defined in this context. Here, we explored the functional role of the transcription factor nuclear factor of activated T-cells 5 (NFAT5/TonEBP) in the hypoxic lung. Regulatory functions of NFAT5 were investigated in cultured artery SM...     »
Zeitschriftentitel:
Cells
Jahr:
2021
Band / Volume:
10
Heft / Issue:
12
Volltext / DOI:
doi:10.3390/cells10123293
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34943801
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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