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Title:

Validation and parameter optimization of a hybrid embedded/homogenized solid tumor perfusion model

Document type:
Zeitschriftenaufsatz
Author(s):
Johannes Kremheller, Sebastian Brandstaeter, Bernhard A. Schrefler, Wolfgang A. Wall
Abstract:
The goal of this paper is to investigate the validity of a hybrid embedded/homogenized in-silico approach for modeling perfusion through solid tumors. The rationale behind this novel idea is that only the larger blood vessels have to be explicitly resolved while the smaller scales of the vasculature are homogenized. As opposed to typical discrete or fully-resolved 1D-3D models, the required data can be obtained with in-vivo imaging techniques since the morphology of the smaller vessels is not ne...     »
Keywords:
microcirculation; tissue perfusion; homogenization; hybrid models; 1D-3D coupling
Dewey Decimal Classification:
620 Ingenieurwissenschaften
Journal title:
International Journal for Numerical Methods in Biomedical Engineering
Year:
2021
Year / month:
2021-08
Covered by:
Scopus
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1002/cnm.3508
WWW:
https://www.researchgate.net/publication/349391667_Validation_and_parameter_optimization_of_a_hybrid_embeddedhomogenized_solid_tumor_perfusion_model
Status:
Verlagsversion / published
Accepted:
02.07.2021
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