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Title:

Purified mucins in drug delivery research

Document type:
Zeitschriftenaufsatz
Author(s):
Marczynski, Matthias; Kimna, Ceren; Lieleg, Oliver
Abstract:
One of the main challenges in the field of drug delivery remains the development of strategies to efficiently transport pharmaceuticals across mucus barriers, which regulate the passage and retention of molecules and particles in all luminal spaces of the body. A thorough understanding of the molecular mechanisms, which govern such selective permeability, is key for achieving efficient translocation of drugs and drug carriers. For this purpose, model systems based on purified mucins can contribu...     »
Keywords:
Drug carriers; Mucin hydrogels; Mucin purification; Mucin solutions; Mucins as active compounds; Mucoadhesion; Mucus model system
Journal title:
Advanced Drug Delivery Reviews
Year:
2021
Journal volume:
178
Pages contribution:
113845
Covered by:
Scopus
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1016/j.addr.2021.113845
WWW:
https://www.sciencedirect.com/science/article/abs/pii/S0169409X21002374
Publisher:
Elsevier BV
E-ISSN:
0169-409X
Date of publication:
01.11.2021
TUM Institution:
Fachgebiet für Biomechanik, MW
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