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Title:

Emulsions of hydrolyzable oils for the zero-order release of hydrophobic drugs

Document type:
Zeitschriftenaufsatz
Author(s):
Tebcharani, Laura; Wanzke, Caren; Lutz, Theresa M.; Rodon-Fores, Jennifer; Lieleg, Oliver; Boekhoven, Job
Abstract:
Drug delivery systems that release hydrophobic drugs with zero-order kinetics remain rare and are often complicated to use. In this work, we present a gellified emulsion (emulgel) that comprises oil droplets of a hydrolyzable oil entrapped in a hydrogel. In the oil, we incorporate various hydrophobic drugs and, because the oil hydrolyzes with zero-order kinetics, the release of the drugs is also linear. We tune the release period from three hours to 50 h by varying the initial oil concentration....     »
Keywords:
Zero-order drug delivery, Sustained-release, Hydrogel Emulgel Emulsion Hydrophobic drug
Journal title:
Journal of Controlled Release
Year:
2021
Journal volume:
339
Pages contribution:
498-505
Covered by:
Scopus
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1016/j.jconrel.2021.10.014
WWW:
https://www.sciencedirect.com/science/article/abs/pii/S0168365921005435
Publisher:
Elsevier BV
E-ISSN:
0168-3659
Date of publication:
01.11.2021
TUM Institution:
Fachgebiet für Biomechanik, MW
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