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Title:

Biopolymer-based nanoparticles with tunable mucoadhesivity efficiently deliver therapeutics across the corneal barrier

Document type:
Zeitschriftenaufsatz
Author(s):
Kimna, Ceren; Winkeljann, Benjamin; Hoffmeister, Julia; Lieleg, Oliver
Abstract:
To overcome the natural barriers of the ocular system that limit the topical delivery of therapeutically active molecules to the posterior eye, nanoscale drug carriers can be used to improve transcorneal drug transport. So far, using mucoadhesive drug carriers has been put forward as the most promising strategy to optimize drug transport. However, if the mucoadhesivity of a drug carrier is too high, this might limit the diffusive entry of molecules/drug carriers into the vitreous. In this study,...     »
Keywords:
Electrospraying; Glaucoma; Ocular drug delivery; Tunable mucoadhesion.
Journal title:
Materials Science and Engineering: C
Year:
2021
Journal volume:
121
Pages contribution:
111890
Covered by:
Scopus
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1016/j.msec.2021.111890
WWW:
https://pubmed.ncbi.nlm.nih.gov/33579502/
Publisher:
Elsevier BV
E-ISSN:
0928-4931
Date of publication:
01.02.2021
TUM Institution:
Professur für Biomechanik
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