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Title:

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.

Document type:
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
Author(s):
Wang, Zhe; Emmerich, Andrew; Pillon, Nicolas J; Moore, Tim; Hemerich, Daiane; Cornelis, Marilyn C; Mazzaferro, Eugenia; Broos, Siacia; Ahluwalia, Tarunveer S; Bartz, Traci M; Bentley, Amy R; Bielak, Lawrence F; Chong, Mike; Chu, Audrey Y; Berry, Diane; Dorajoo, Rajkumar; Dueker, Nicole D; Kasbohm, Elisa; Feenstra, Bjarke; Feitosa, Mary F; Gieger, Christian; Graff, Mariaelisa; Hall, Leanne M; Haller, Toomas; Hartwig, Fernando P; Hillis, David A; Huikari, Ville; Heard-Costa, Nancy; Holzapfel, Chri...     »
Abstract:
Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for...     »
Journal title abbreviation:
Nat Genet
Year:
2022
Journal volume:
54
Journal issue:
9
Pages contribution:
1332-1344
Fulltext / DOI:
doi:10.1038/s41588-022-01165-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36071172
Print-ISSN:
1061-4036
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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