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Title:

Specification of CNS macrophage subsets occurs postnatally in defined niches.

Document type:
Article; Journal Article
Author(s):
Masuda, Takahiro; Amann, Lukas; Monaco, Gianni; Sankowski, Roman; Staszewski, Ori; Krueger, Martin; Del Gaudio, Francesca; He, Liqun; Paterson, Neil; Nent, Elisa; Fernández-Klett, Francisco; Yamasaki, Ayato; Frosch, Maximilian; Fliegauf, Maximilian; Bosch, Lance Fredrick Pahutan; Ulupinar, Hatice; Hagemeyer, Nora; Schreiner, Dietmar; Dorrier, Cayce; Tsuda, Makoto; Grothe, Claudia; Joutel, Anne; Daneman, Richard; Betsholtz, Christer; Lendahl, Urban; Knobeloch, Klaus-Peter; Lämmermann, Tim; Prille...     »
Abstract:
All tissue-resident macrophages of the central nervous system (CNS)-including parenchymal microglia, as well as CNS-associated macrophages (CAMs1) such as meningeal and perivascular macrophages2-7-are part of the CNS endogenous innate immune system that acts as the first line of defence during infections or trauma2,8-10. It has been suggested that microglia and all subsets of CAMs are derived from prenatal cellular sources in the yolk sac that were defined as early erythromyeloid progenitors11-1...     »
Journal title abbreviation:
Nature
Year:
2022
Journal volume:
604
Journal issue:
7907
Pages contribution:
740-748
Fulltext / DOI:
doi:10.1038/s41586-022-04596-2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35444273
Print-ISSN:
0028-0836
TUM Institution:
Klinik und Poliklinik für Psychiatrie und Psychotherapie
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