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- Dokumenttyp:
- Article; Journal Article; Research Support, Non-U.S. Gov't
- Autor(en):
- Miller, Duncan C; Lisowski, Pawel; Lickfett, Selene; Mlody, Barbara; Bünning, Miriam; Genehr, Carolin; Ulrich, Claas; Wanker, Erich E; Diecke, Sebastian; Priller, Josef; Prigione, Alessandro
- Titel:
- Generation of induced pluripotent stem cells from three individuals with Huntington's disease.
- Abstract:
- Huntington's disease (HD) is a neurodegenerative disorder caused by abnormal glutamine (Q) expansion in the huntingtin protein due to elongated CAG repeats in the gene HTT. We used non-integrative episomal plasmids to generate induced pluripotent stem cells (iPSCs) from three individuals affected by HD: CH1 (58Q), and two twin brothers CH3 (44Q) and CH4 (44Q). The iPSC lines exhibited one healthy HTT allele and one with elongated CAG repeats, as confirmed by PCR and sequencing. All iPSC lines ex... »
- Zeitschriftentitel:
- Stem Cell Res
- Jahr:
- 2022
- Band / Volume:
- 65
- Volltext / DOI:
- doi:10.1016/j.scr.2022.102976
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/36434993
- Print-ISSN:
- 1873-5061
- TUM Einrichtung:
- Klinik und Poliklinik für Psychiatrie und Psychotherapie
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