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Title:

Fatigue, depression, and pain in multiple sclerosis: How neuroinflammation translates into dysfunctional reward processing and anhedonic symptoms.

Document type:
Journal Article
Author(s):
Heitmann, Henrik; Andlauer, Till F M; Korn, Thomas; Mühlau, Mark; Henningsen, Peter; Hemmer, Bernhard; Ploner, Markus
Abstract:
Fatigue, depression, and pain affect the majority of multiple sclerosis (MS) patients, which causes a substantial burden to patients and society. The pathophysiology of these symptoms is not entirely clear, and current treatments are only partially effective. Clinically, these symptoms share signs of anhedonia, such as reduced motivation and a lack of positive affect. In the brain, they are associated with overlapping structural and functional alterations in areas involved in reward processing....     »
Journal title abbreviation:
Mult Scler
Year:
2022
Journal volume:
28
Journal issue:
7
Pages contribution:
1020-1027
Fulltext / DOI:
doi:10.1177/1352458520972279
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33179588
Print-ISSN:
1352-4585
TUM Institution:
Klinik und Poliklinik für Neurologie; Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie; Molekulare Immunologie (Prof. Knolle); Professur für Human Pain Research (Prof. Ploner)
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