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Titel:

Siponimod Inhibits the Formation of Meningeal Ectopic Lymphoid Tissue in Experimental Autoimmune Encephalomyelitis.

Dokumenttyp:
Journal Article
Autor(en):
Brand, Rosa Margareta; Diddens, Jolien; Friedrich, Verena; Pfaller, Monika; Radbruch, Helena; Hemmer, Bernhard; Steiger, Katja; Lehmann-Horn, Klaus
Abstract:
BACKGROUND AND OBJECTIVES: To investigate whether the formation or retention of meningeal ectopic lymphoid tissue (mELT) can be inhibited by the sphingosine 1-phosphate receptor 1,5 modulator siponimod (BAF312) in a murine model of multiple sclerosis (MS). METHODS: A murine spontaneous chronic experimental autoimmune encephalomyelitis (EAE) model, featuring meningeal inflammatory infiltrates resembling those in MS, was used. To prevent or treat EAE, siponimod was administered daily starting eith...     »
Zeitschriftentitel:
Neurol Neuroimmunol Neuroinflamm
Jahr:
2022
Band / Volume:
9
Heft / Issue:
1
Volltext / DOI:
doi:10.1212/NXI.0000000000001117
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34911793
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Neurologie
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