Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies exhibiting the strongest association with blood coagulation. The recruitment of non-classical monocytes (nMs) was highly associated with procoagulant activities. The recruitment of nMs was associated with reduced tumor cell extravasation at the site of metastasis in experiments using cell line 8182, whereas they were linked to increased extravasation of cell line 53631, which released large amounts of extracellular vesicles (EVs). Thus, nMs might play a dual role in PDAC extravasation.
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Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies exhibiting the strongest association with blood coagulation. The recruitment of non-classical monocytes (nMs) was highly associated with procoagulant activities. The recruitment of nMs was associated with reduced tumor cell extravasation at the site of metastasis in experiments using cell line 8182, whereas they were linked to increased extravasation of cell line 53631, which released large amounts of extracellular ve...
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