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Document type:
Review; Journal Article; Review
Author(s):
Kunzelmann, Karl; Ousingsawat, Jiraporn; Cabrita, Inês; Doušová, Tereza; Bähr, Andrea; Janda, Melanie; Schreiber, Rainer; Benedetto, Roberta
Title:
TMEM16A in Cystic Fibrosis: Activating or Inhibiting?
Abstract:
The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is dysfunctional in CF, leading to defects in epithelial transport. Although CF pathogenesis is still disputed, activation of alternative Cl- channels is assumed to improve lung function in CF. Two suitable non-CFTR Cl- channels are present in the airway ep...     »
Journal title abbreviation:
Front Pharmacol
Year:
2019
Journal volume:
10
Fulltext / DOI:
doi:10.3389/fphar.2019.00003
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30761000
TUM Institution:
1693; Klinik und Poliklinik für Innere Medizin I, Kardiologie
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