Benutzer: Gast  Login
Titel:

TMEM16A in Cystic Fibrosis: Activating or Inhibiting?

Dokumenttyp:
Review; Journal Article; Review
Autor(en):
Kunzelmann, Karl; Ousingsawat, Jiraporn; Cabrita, Inês; Doušová, Tereza; Bähr, Andrea; Janda, Melanie; Schreiber, Rainer; Benedetto, Roberta
Abstract:
The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is dysfunctional in CF, leading to defects in epithelial transport. Although CF pathogenesis is still disputed, activation of alternative Cl- channels is assumed to improve lung function in CF. Two suitable non-CFTR Cl- channels are present in the airway ep...     »
Zeitschriftentitel:
Front Pharmacol
Jahr:
2019
Band / Volume:
10
Volltext / DOI:
doi:10.3389/fphar.2019.00003
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30761000
TUM Einrichtung:
1693; Klinik und Poliklinik für Innere Medizin I, Kardiologie
 BibTeX