Cardiac MRI shows an association of lower cardiorespiratory fitness with decreased myocardial mass and higher cardiac stiffness in the general population - The Sedentary's Heart.

Markus, Marcello Ricardo Paulista; Ittermann, Till; Drzyzga, Christine Julia; Bahls, Martin; Schipf, Sabine; Siewert-Markus, Ulrike; Baumeister, Sebastian Edgar; Schumacher, Paul; Ewert, Ralf; Völzke, Henry; Steinhagen-Thiessen, Elisabeth; Bülow, Robin; Schunkert, Heribert; Vasan, Ramachandran S; Felix, Stephan Burkhard; Dörr, Marcus

doi:10.1016/j.pcad.2021.09.003

2021

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Document type:: Review; Journal Article; Research Support, Non-U.S. Gov't
Author(s):: Markus, Marcello Ricardo Paulista; Ittermann, Till; Drzyzga, Christine Julia; Bahls, Martin; Schipf, Sabine; Siewert-Markus, Ulrike; Baumeister, Sebastian Edgar; Schumacher, Paul; Ewert, Ralf; Völzke, Henry; Steinhagen-Thiessen, Elisabeth; Bülow, Robin; Schunkert, Heribert; Vasan, Ramachandran S; Felix, Stephan Burkhard; Dörr, Marcus
Title:: Cardiac MRI shows an association of lower cardiorespiratory fitness with decreased myocardial mass and higher cardiac stiffness in the general population - The Sedentary's Heart.
Abstract:: BACKGROUND: The heart has the capacity to adapt to different demands. The pathophysiological mechanisms involved with sedentarism are not fundamentally the opposite of those related with physical activity and regular exercise. We investigated the impact of lower cardiorespiratory fitness (CRF) on heart's plasticity and function in a population-based setting. METHODS: We used data from 1165 participants (539 women; 46.3%) aged 21-81 years from two independent cohorts of the Study of Health in Pomerania (SHIP-2 and SHIP-TREND-0). We analyzed the cross-sectional associations of peak oxygen uptake (VO2peak), determined by symptom-limited cardiopulmonary exercise testing, with structural and functional left ventricular (LV) and left atrial (LA) parameters determined by magnetic resonance imaging (MRI) using multivariable- adjusted linear regression models. RESULTS: A 1 L/min lower VO2peak was associated with a 10.5 g (95% confidence interval: 8.00 to 12.9; p < 0.001) lower LV mass, a 14.8 mL (10.9 to 18.6; p < 0.001) lower LV end-diastolic volume, a 0.29 mm (0.19 to 0.40; p < 0.001) lower LV wall-thickness, a 8.85 mL/beat (6.53 to 11.2; p < 0.001) lower LV stroke volume, a 0.42 L/min (0.25 to 0.60; p < 0.001) lower LV cardiac output and a 7.51 mL (3.88 to 11.1; p < 0.001) lower LA end-diastolic volume. Moreover, there were no associations with a concentric or eccentric remodeling and LV and LA ejection fraction. CONCLUSIONS: Lower CRF was associated with a smaller heart, LV wall-thickness and mass, LV and LA stroke volume and cardiac output. Conversely, there was no association with LA and LV ejection fraction. Our cross-sectional observations are consistent with cardiac adaptations reflecting reduced volume loading demands of a sedentary lifestyle - "the sedentary's heart".
Journal title abbreviation:: Prog Cardiovasc Dis
Year:: 2021
Journal volume:: 68
Pages contribution:: 25-35
Fulltext / DOI:: doi:10.1016/j.pcad.2021.09.003
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/34537204
Print-ISSN:: 0033-0620
TUM Institution:: Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (DHM) (Prof. Schunkert)2021