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Titel:

Human Engineered Heart Tissue Patches Remuscularize the Injured Heart in a Dose-Dependent Manner.

Dokumenttyp:
Journal Article
Autor(en):
Querdel, Eva; Reinsch, Marina; Castro, Liesa; Köse, Deniz; Bähr, Andrea; Reich, Svenja; Geertz, Birgit; Ulmer, Bärbel; Schulze, Mirja; Lemoine, Marc D; Krause, Tobias; Lemme, Marta; Sani, Jascha; Shibamiya, Aya; Stüdemann, Tim; Köhne, Maria; Bibra, Constantin von; Hornaschewitz, Nadja; Pecha, Simon; Nejahsie, Yusuf; Mannhardt, Ingra; Christ, Torsten; Reichenspurner, Hermann; Hansen, Arne; Klymiuk, Nikolai; Krane, M; Kupatt, C; Eschenhagen, Thomas; Weinberger, Florian
Abstract:
BACKGROUND: Human engineered heart tissue (EHT) transplantation represents a potential regenerative strategy for patients with heart failure and has been successful in preclinical models. Clinical application requires upscaling, adaptation to good manufacturing practices, and determination of the effective dose. METHODS: Cardiomyocytes were differentiated from 3 different human induced pluripotent stem cell lines including one reprogrammed under good manufacturing practice conditions. Protocols...     »
Zeitschriftentitel:
Circulation
Jahr:
2021
Band / Volume:
143
Heft / Issue:
20
Seitenangaben Beitrag:
1991-2006
Volltext / DOI:
doi:10.1161/CIRCULATIONAHA.120.047904
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33648345
Print-ISSN:
0009-7322
TUM Einrichtung:
1693; Klinik für Herz- und Gefäßchirurgie (Prof. Lange)
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