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Titel:

New generation ENaC inhibitors detach cystic fibrosis airway mucus bundles via sodium/hydrogen exchanger inhibition.

Dokumenttyp:
Journal Article
Autor(en):
Giorgetti, Melania; Klymiuk, Nikolai; Bähr, Andrea; Hemmerling, Martin; Jinton, Lisa; Tarran, Robert; Malmgren, Anna; Åstrand, Annika; Hansson, Gunnar C; Ermund, Anna
Abstract:
Cystic fibrosis (CF) is a recessive inherited disease caused by mutations affecting anion transport by the epithelial ion channel cystic fibrosis transmembrane conductance regulator (CFTR). The disease is characterized by mucus accumulation in the airways and intestine, but the major cause of mortality in CF is airway mucus accumulation, leading to bacterial colonization, inflammation and respiratory failure. Several drug targets are under evaluation to alleviate airway mucus obstruction in CF a...     »
Zeitschriftentitel:
Eur J Pharmacol
Jahr:
2021
Band / Volume:
904
Volltext / DOI:
doi:10.1016/j.ejphar.2021.174123
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33974881
Print-ISSN:
0014-2999
TUM Einrichtung:
1693; Klinik und Poliklinik für Innere Medizin I, Kardiologie
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