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Title:

Human Engineered Heart Tissue Patches Remuscularize the Injured Heart in a Dose-Dependent Manner.

Document type:
Journal Article
Author(s):
Querdel, Eva; Reinsch, Marina; Castro, Liesa; Köse, Deniz; Bähr, Andrea; Reich, Svenja; Geertz, Birgit; Ulmer, Bärbel; Schulze, Mirja; Lemoine, Marc D; Krause, Tobias; Lemme, Marta; Sani, Jascha; Shibamiya, Aya; Stüdemann, Tim; Köhne, Maria; Bibra, Constantin von; Hornaschewitz, Nadja; Pecha, Simon; Nejahsie, Yusuf; Mannhardt, Ingra; Christ, Torsten; Reichenspurner, Hermann; Hansen, Arne; Klymiuk, Nikolai; Krane, M; Kupatt, C; Eschenhagen, Thomas; Weinberger, Florian
Abstract:
BACKGROUND: Human engineered heart tissue (EHT) transplantation represents a potential regenerative strategy for patients with heart failure and has been successful in preclinical models. Clinical application requires upscaling, adaptation to good manufacturing practices, and determination of the effective dose. METHODS: Cardiomyocytes were differentiated from 3 different human induced pluripotent stem cell lines including one reprogrammed under good manufacturing practice conditions. Protocols...     »
Journal title abbreviation:
Circulation
Year:
2021
Journal volume:
143
Journal issue:
20
Pages contribution:
1991-2006
Fulltext / DOI:
doi:10.1161/CIRCULATIONAHA.120.047904
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33648345
Print-ISSN:
0009-7322
TUM Institution:
1693; Klinik für Herz- und Gefäßchirurgie (Prof. Lange)
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