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Title:

New generation ENaC inhibitors detach cystic fibrosis airway mucus bundles via sodium/hydrogen exchanger inhibition.

Document type:
Journal Article
Author(s):
Giorgetti, Melania; Klymiuk, Nikolai; Bähr, Andrea; Hemmerling, Martin; Jinton, Lisa; Tarran, Robert; Malmgren, Anna; Åstrand, Annika; Hansson, Gunnar C; Ermund, Anna
Abstract:
Cystic fibrosis (CF) is a recessive inherited disease caused by mutations affecting anion transport by the epithelial ion channel cystic fibrosis transmembrane conductance regulator (CFTR). The disease is characterized by mucus accumulation in the airways and intestine, but the major cause of mortality in CF is airway mucus accumulation, leading to bacterial colonization, inflammation and respiratory failure. Several drug targets are under evaluation to alleviate airway mucus obstruction in CF a...     »
Journal title abbreviation:
Eur J Pharmacol
Year:
2021
Journal volume:
904
Fulltext / DOI:
doi:10.1016/j.ejphar.2021.174123
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33974881
Print-ISSN:
0014-2999
TUM Institution:
1693; Klinik und Poliklinik für Innere Medizin I, Kardiologie
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