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Title:

CFTR Correctors and Antioxidants Partially Normalize Lipid Imbalance but not Abnormal Basal Inflammatory Cytokine Profile in CF Bronchial Epithelial Cells.

Document type:
Journal Article
Author(s):
Veltman, Mieke; De Sanctis, Juan B; Stolarczyk, Marta; Klymiuk, Nikolai; Bähr, Andrea; Brouwer, Rutger W; Oole, Edwin; Shah, Juhi; Ozdian, Tomas; Liao, Jie; Martini, Carolina; Radzioch, Danuta; Hanrahan, John W; Scholte, Bob J
Abstract:
A deficiency in cystic fibrosis transmembrane conductance regulator (CFTR) function in CF leads to chronic lung disease. CF is associated with abnormalities in fatty acids, ceramides, and cholesterol, their relationship with CF lung pathology is not completely understood. Therefore, we examined the impact of CFTR deficiency on lipid metabolism and pro-inflammatory signaling in airway epithelium using mass spectrometric, protein array. We observed a striking imbalance in fatty acid and ceramide m...     »
Journal title abbreviation:
Front Physiol
Year:
2021
Journal volume:
12
Fulltext / DOI:
doi:10.3389/fphys.2021.619442
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33613309
Print-ISSN:
1664-042X
TUM Institution:
1693
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