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Title:

Cold non-ischemic heart preservation with continuous perfusion prevents early graft failure in orthotopic pig-to-baboon xenotransplantation.

Document type:
Article; Journal Article
Author(s):
Längin, Matthias; Reichart, Bruno; Steen, Stig; Sjöberg, Trygve; Paskevicius, Audrius; Liao, Qiuming; Qin, Guangqi; Mokelke, Maren; Mayr, Tanja; Radan, Julia; Issl, Lara; Buttgereit, Ines; Ying, Jiawei; Fresch, Ann Kathrin; Panelli, Alessandro; Egerer, Stefanie; Bähr, Andrea; Kessler, Barbara; Milusev, Anastasia; Sfriso, Riccardo; Rieben, Robert; Ayares, David; Murray, Peter J; Ellgass, Reinhard; Walz, Christoph; Klymiuk, Nikolai; Wolf, Eckhard; Abicht, Jan-Michael; Brenner, Paolo
Abstract:
BACKGROUND: Successful preclinical transplantations of porcine hearts into baboon recipients are required before commencing clinical trials. Despite years of research, over half of the orthotopic cardiac xenografts were lost during the first 48 hours after transplantation, primarily caused by perioperative cardiac xenograft dysfunction (PCXD). To decrease the rate of PCXD, we adopted a preservation technique of cold non-ischemic perfusion for our ongoing pig-to-baboon cardiac xenotransplantation...     »
Journal title abbreviation:
Xenotransplantation
Year:
2021
Journal volume:
28
Journal issue:
1
Fulltext / DOI:
doi:10.1111/xen.12636
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32841431
Print-ISSN:
0908-665X
TUM Institution:
1693; Klinik und Poliklinik für Innere Medizin I, Kardiologie
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