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- Document type:
- Article; Journal Article; Research Support, Non-U.S. Gov't
- Author(s):
- Bourier, Felix; Vlachos, Konstantinos; Frontera, Antonio; Martin, Claire A; Lam, Anna; Takigawa, Masateru; Kitamura, Takeshi; Cheniti, Ghassen; Duchateau, Josselin; Pambrun, Thomas; Derval, Nicolas; Denis, Arnaud; Cochet, Hubert; Hocini, Mélèze; Sacher, Frédéric; Haïssaguerre, Michel; Jaïs, Pierre
- Title:
- In silico analysis of the relation between conventional and high-power short-duration RF ablation settings and resulting lesion metrics.
- Abstract:
- BACKGROUND: Use of lesion metric indices is a proposed strategy to support pulmonary vein isolation procedures and these indices show good correlations with lesion sizes. The aim of this in silico study is to provide a detailed analysis of radiofrequency (RF) settings, including high-power short-duration (HPSD) settings, and resulting lesion metric indices. METHODS AND RESULTS: A software program was designed which simulated virtual RF ablations. Lesion metric indices (Ablation index: AI, Lesion size index: LSI) were calculated based on underlying RF settings (contact force [CF], power, duration). In series of calculations, the applied settings were varied within defined ranges (CF: 1-80 g, power: 1-60 W, duration: 1-60 seconds). Overall, n = 388 000 virtual ablations were calculated. The resulting lesion metric indices were compared with each other and analyzed in relation to respective RF settings. Increasing contact force from 1 to 10 g resulted in a 4.4-fold LSI value, whilst increasing contact force from 10 to 20g resulted in a 1.5-fold value (P < .01). When RF power was increased by 10 W, lesion metric indices increased between 1.3- and 1.6-fold. A prolongation of RF duration by 10 seconds resulted in a 1.2-to-1.3-fold increase of lesion metric indices. HPSD RF applications of 50 W, 11 to 13 seconds, and 60 W, 8 to 10 seconds resulted in equivalent lesion metric indices when compared with 30 W, 30 seconds conventional ablations. CONCLUSIONS: The findings support the clinical use of contact forces within a 10 to 20 g range. AI is more sensitive to RF duration, whereas LSI is more sensitive to contact force. HPSD RF settings can successfully be derived from lesion metric indices.
- Journal title abbreviation:
- J Cardiovasc Electrophysiol
- Year:
- 2020
- Journal volume:
- 31
- Journal issue:
- 6
- Pages contribution:
- 1332-1339
- Fulltext / DOI:
- doi:10.1111/jce.14495
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/32282970
- Print-ISSN:
- 1045-3873
- TUM Institution:
- Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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