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- Title:
Pulmonary stretch receptor activity during partial liquid ventilation with different pressure waveforms.
- Document type:
- Journal Article; Research Support, Non-U.S. Gov't
- Author(s):
- Rieger-Fackeldey, Esther; Jonzon, Anders; Schulze, Andreas; Sedin, Gunnar; Sindelar, Richard
- Abstract:
- BACKGROUND: The aim of the present study was to investigate pulmonary stretch receptor activity (PSR) under different peak inspiratory pressures (PIPs) and inspiratory pressure waveforms during partial liquid (PLV) and gas ventilation (GV). METHODS: PSR instantaneous impulse frequency (PSRfimp) was recorded from single fibers in the vagal nerve during PLV and GV in young cats. PIPs were set at 1.2/1.8/2.2/2.7 kPa, and square and sinusoidal pressure waveforms were applied. RESULTS: PSRfimp at the start of inspiration increased with increasing PIPs, and was steeper and higher with square than with sinusoidal waveforms (p < 0.05). Total number of impulses, peak and mean PSRfimp were lower during PLV than GV at the lowest and highest PIPs (p < 0.025). Time to peak PSRfimp was shorter with square than with sinusoidal waveforms at all pressures and ventilations (p < 0.005). Irrespective of waveform, lower PIPs yielded lower ventilation during PLV. CONCLUSION: As assessed by PSRfimp, increased PIPs do not expose the lungs to more stretching during PLV than during GV, with only minor differences between square and sinusoidal waveforms.
- Journal title abbreviation:
- Respir Physiol Neurobiol
- Year:
- 2020
- Journal volume:
- 276
- Fulltext / DOI:
- doi:10.1016/j.resp.2020.103413
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/32044447
- Print-ISSN:
- 1569-9048
- TUM Institution:
- Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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