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Title:

Overactivation of the IGF signalling pathway in osteosarcoma: a potential therapeutic target?

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Ameline, Baptiste; Kovac, Michal; Nathrath, Michaela; Barenboim, Maxim; Witt, Olaf; Krieg, Andreas H; Baumhoer, Daniel
Abstract:
Osteosarcoma is the most common primary malignant bone tumour in children and adolescents. More than a third of patients do not respond to standard therapy and urgently require alternative treatment options. Due to a high degree of inter- and intra-tumoural genomic heterogeneity and complexity, recurrent molecular alterations that could serve as prognostic predictors or therapeutic targets are still lacking in osteosarcoma. Copy number (CN) gains involving the IGF1R gene, however, have been sugg...     »
Journal title abbreviation:
J Pathol Clin Res
Year:
2021
Journal volume:
7
Journal issue:
2
Pages contribution:
165-172
Fulltext / DOI:
doi:10.1002/cjp2.191
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33295144
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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