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Titel:

Overactivation of the IGF signalling pathway in osteosarcoma: a potential therapeutic target?

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Ameline, Baptiste; Kovac, Michal; Nathrath, Michaela; Barenboim, Maxim; Witt, Olaf; Krieg, Andreas H; Baumhoer, Daniel
Abstract:
Osteosarcoma is the most common primary malignant bone tumour in children and adolescents. More than a third of patients do not respond to standard therapy and urgently require alternative treatment options. Due to a high degree of inter- and intra-tumoural genomic heterogeneity and complexity, recurrent molecular alterations that could serve as prognostic predictors or therapeutic targets are still lacking in osteosarcoma. Copy number (CN) gains involving the IGF1R gene, however, have been sugg...     »
Zeitschriftentitel:
J Pathol Clin Res
Jahr:
2021
Band / Volume:
7
Heft / Issue:
2
Seitenangaben Beitrag:
165-172
Volltext / DOI:
doi:10.1002/cjp2.191
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33295144
TUM Einrichtung:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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