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Titel:

Multisystem inflammation and susceptibility to viral infections in human ZNFX1 deficiency.

Dokumenttyp:
Journal Article
Autor(en):
Vavassori, Stefano; Chou, Janet; Faletti, Laura Eva; Haunerdinger, Veronika; Opitz, Lennart; Joset, Pascal; Fraser, Christopher J; Prader, Seraina; Gao, Xianfei; Schuch, Luise A; Wagner, Matias; Hoefele, Julia; Maccari, Maria Elena; Zhu, Ying; Elakis, George; Gabbett, Michael T; Forstner, Maria; Omran, Heymut; Kaiser, Thomas; Kessler, Christina; Olbrich, Heike; Frosk, Patrick; Almutairi, Abduarahman; Platt, Craig D; Elkins, Megan; Weeks, Sabrina; Rubin, Tamar; Planas, Raquel; Marchetti, Tommaso;...     »
Abstract:
BACKGROUND: Recognition of viral nucleic acids is one of the primary triggers for a type I interferon-mediated antiviral immune response. Inborn errors of type I interferon immunity can be associated with increased inflammation and/or increased susceptibility to viral infections as a result of dysbalanced interferon production. NFX1-type zinc finger-containing 1 (ZNFX1) is an interferon-stimulated double-stranded RNA sensor that restricts the replication of RNA viruses in mice. The role of ZNFX1...     »
Zeitschriftentitel:
J Allergy Clin Immunol
Jahr:
2021
Band / Volume:
148
Heft / Issue:
2
Seitenangaben Beitrag:
381-393
Volltext / DOI:
doi:10.1016/j.jaci.2021.03.045
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33872655
Print-ISSN:
0091-6749
TUM Einrichtung:
611; Institut für Humangenetik
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