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Title:

Compression and stretch sensitive submucosal neurons of the porcine and human colon.

Document type:
Article; Journal Article; Research Support, N.I.H., Extramural
Author(s):
Filzmayer, Anna Katharina; Elfers, Kristin; Michel, Klaus; Buhner, Sabine; Zeller, Florian; Demir, Ihsan Ekin; Theisen, Jörg; Schemann, Michael; Mazzuoli-Weber, Gemma
Abstract:
The pig is commonly believed to be a relevant model for human gut functions-however, there are only a few comparative studies and none on neural control mechanisms. To address this lack we identified as one central aspect mechanosensitive enteric neurons (MEN) in porcine and human colon. We used neuroimaging techniques to record responses to tensile or compressive forces in submucous neurons. Compression and stretch caused Ca-transients and immediate spike discharge in 5-11% of porcine and 15-24...     »
Journal title abbreviation:
Sci Rep
Year:
2020
Journal volume:
10
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41598-020-70216-6
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32796868
Print-ISSN:
2045-2322
TUM Institution:
Chirurgische Klinik und Poliklinik
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