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Titel:

Targeting Aggressive Fibroblasts to Enhance the Treatment of Pancreatic Cancer.

Dokumenttyp:
Review; Journal Article
Autor(en):
Yu, Yuanyuan; Schuck, Kathleen; Friess, Helmut; Kong, Bo
Abstract:
INTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant cancer entities, which is characterized by abundant desmoplastic stroma. The stroma consists of extracellular matrix, infiltrating immune cells, cancer-associated fibroblasts (CAFs) and others. Depending on environmental cues, CAFs can be highly heterogeneous and play context-dependent roles in PDAC progression. AREAS COVERED: In this article, we discuss the biological significance of CAFs heterogeneity (oncogenic...     »
Zeitschriftentitel:
Expert Opin Ther Targets
Jahr:
2021
Band / Volume:
25
Heft / Issue:
1
Seitenangaben Beitrag:
5-13
Volltext / DOI:
doi:10.1080/14728222.2021.1857727
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33246383
Print-ISSN:
1472-8222
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
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