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Titel:

Dual role of neutrophils in modulating liver injury and fibrosis during development and resolution of diet-induced murine steatohepatitis.

Dokumenttyp:
Article; Journal Article; Research Support, N.I.H., Extramural
Autor(en):
Kim, Andrea D; Kim, Sung Eun; Leszczynska, Aleksandra; Kaufmann, Benedikt; Reca, Agustina; Kim, Dong Joon; Feldstein, Ariel E
Abstract:
Inflammatory changes in the liver represent a key feature of non-alcoholic steatohepatitis (NASH), the progressive form of non-alcoholic fatty liver disease (NAFLD). Innate immune activation including hepatic neutrophilic infiltration acts as an important inflammatory trigger as well as a potential mediator of inflammation resolution. In this study, we dissected the effects of neutrophil depletion via anti-lymphocyte antigen 6 complex locus G6D (Ly6G) antibodies administration during ongoing hig...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2021
Band / Volume:
11
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41598-021-03679-w
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34921208
Print-ISSN:
2045-2322
TUM Einrichtung:
Klinik und Poliklinik für Chirurgie
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